Anti-Inflammatory and Cardioprotective Effects of Tadalafil in Diabetic Mice
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چکیده
منابع مشابه
Anti-Inflammatory and Cardioprotective Effects of Tadalafil in Diabetic Mice
BACKGROUND Insulin resistance impairs nitric oxide (NO) bioavailability and obesity promotes a state of chronic inflammation and damages the vascular endothelium. Phosphodiesterase-5 inhibitors restore NO signaling and may reduce circulating inflammatory markers, and improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor, ta...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0045243